Safety and efficacy of a strategy of vitamin K antagonist reversal with prothrombin complex concentrates compared to vitamin K in patients with hip fracture
نویسندگان
چکیده
منابع مشابه
Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis.
Prothrombin complex concentrates (PCCs) are recommended as the treatment of choice in warfarin-related coagulopathy. However, the risk of thromboembolic complications associated with their use is not well defined. We performed a meta-analysis to estimate the rate of thromboembolic complications in patients receiving vitamin K antagonists (VKAs) treated with PCCs for bleeding or before urgent su...
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15 صفحه اولIncreased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversal.
BACKGROUND Plasma is commonly used for vitamin K antagonist (VKA) reversal, but observational studies suggest that it is associated with transfusion-related adverse reactions (e.g., volume overload). However, this issue has not previously been addressed in a randomized controlled trial (RCT). STUDY DESIGN AND METHODS Factors associated with volume overload were examined using data from two Ph...
متن کاملProthrombin complex concentrates for reversal of vitamin K antagonists: assessing the risks.
Vitamin K antagonists (VKA) have been the standard for the treatment and prevention of thromboembolism in patients with atrial fibrillation, venous thromboembolism and prosthetic heart valves for more than 50 years. In 2004, more than 30 million prescriptions for warfarin were written in the United States (1). VKA are subject to significant dietand drug-drug interactions; therefore, it is not s...
متن کاملTreatment with vitamin K in hip fracture patients receiving warfarin.
BACKGROUND Hip fractures are common in the elderly population, but surgical treatment of these fractures within the first 48 hours decreases morbidity and mortality. The management of patients with hip fracture requiring surgery who are taking warfarin anticoagulation is unclear. OBJECTIVES To determine the effect of vitamin K on hip fracture patients treated with warfarin. METHODS We retro...
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ژورنال
عنوان ژورنال: Canadian Journal of Surgery
سال: 2021
ISSN: 0008-428X
DOI: 10.1503/cjs.002120